That heartbreaking statistic is but one symptom of an epidemic that shows no sign of abating. The 33,000 overdose deaths from opioids in 2015 were a 16 percent rise over the previous year, which also set a record. Drug overdoses are now a leading cause of death among Americans under 50—but only part of a broader addiction landscape that ranges from drug and alcohol abuse to obsessive eating, gambling, and even sex.